Immunotoxins (ITs) are chimeric molecules constructed by covalently conjugating
monoclonal antibodies (MoAbs) to plant or bacterial toxins (eg ricin or pseudomonas …

Polynucleotide: adenosine glycosidases (rRNA N-glycosidases, EC 3.2. 2.22, more
commonly known as ribosome-inactivating proteins, RIP) are a numerous family of plant and …

The intent of this article is to review recent literature on ribosome inactivating proteins (RIPs)
including isolation and characterization of new RIPs, studies on the crystal structures and …

Immunotoxins are targeted therapeutics designed to kill cancer cells. The targeting moiety of
an immunotoxin selectively binds to a tumor cell and targets it for death via an attached …

Despite the progress of the bioinformatics approach to characterize cell‐surface antigens
and receptors on tumor cells, it remains difficult to generate novel cancer vaccines or …

Immunotoxins were prepared with several single-chain ribosome-inactivating proteins (RIPs
type 1) and with the A-chain of ricin linked to the F (ab′) 2 fragment of sheep anti-mouse …

Immunotoxins were prepared with three ribosome‐inactivating proteins (RIP), momordin,
pokeweed antiviral protein from seeds (PAP‐S) and saporin‐S6, linked to the anti‐CD22 …

The seeds of the plant Trichosanthes anguina contain a type I ribosome-inactivating protein
(RIP), designated trichoanguin, which was purified to apparent homogeneity by the …

Background Immunotherapy is fast emerging as one of the leading modes of treatment of
cancer, in combination with chemotherapy and radiation. Use of immunotoxins, proteins …

Immunotoxins are proteins that contain a toxin along with an antibody or growth factor that
binds specifically to target cells. Nearly all protein toxins work by enzymatically inhibiting …