A panel of immunotoxins was constructed by chemically attaching the ribosome-inactivating
proteins abrin A chain, ricin A chain, gelonin, and momordin to the monoclonal mouse IgG2a …

Immunotoxins are chimeric molecules, which combine antibody specificity to recognize and
bind with high-affinity tumor-associated antigens (TAA) with the potency of the enzymatic …

An immunotoxin was synthesized by the attachment of α‐sarcin, the ribosome‐inactivating
protein derived from the mould Aspergillus giganteus, to a monoclonal mouse IgG2a …

Immunotoxins, which are conjugates of cell-binding antibodies and toxins, show
considerable promise in the treatment of certain cancers. Genetic engineering is …

Shiga-like toxins and ricin are ribosome-inactivating proteins (RIPs) that are lethal to
mammals and pose a global health threat. No clinical vaccines or therapeutics currently …

Immunotoxins are proteins used to treat cancer that are composed of an antibody fragment
linked to a toxin. The immunotoxin binds to a surface antigen on a cancer cell, enters the cell …

Targeted cancer therapies using immunotoxins have achieved remarkable efficacy in
hematological malignancies. However, the clinical development of immunotoxins is also …

Immunotoxins (ITXs) are chimeric molecules that combine the specificity of a targeting
domain, usually derived from an antibody, and the cytotoxic potency of a toxin, leading to the …

The toxic moiety of almost all protein-based targeted toxins must enter the cytosol of the
target cell to mediate its fatal effect. Although more than 500 targeted toxins have been …

Targeted therapeutics are potential therapeutic agents because of their selectivity and
efficacy against tumors resistant to conventional therapy. The goal of this study was to …