Background H 4 receptor antagonists are potential novel treatments for inflammatory skin
diseases, including atopic dermatitis (AD). Objective We sought to study the efficacy and …

This trial was conducted to evaluate the safety and efficacy of the H4R‐antagonist JNJ‐
39758979 in adult Japanese patients with moderate atopic dermatitis (AD). Eligible patients …

The histamine H4 receptor (H4R), a member of the G-protein coupled receptor family, has
been considered as a potential therapeutic target for treating atopic dermatitis (AD). A large …

Histamine plays important roles in inflammation and nervous irritability in allergic disorders,
including atopic dermatitis (AD). It has been shown to regulate the expression of pruritic …

Background The histamine H4 receptor (H4R) was brought into focus as a new therapeutic
target for the treatment of allergic disorders such as atopic dermatitis (AD). H4R antagonists …

Atopic dermatitis (AD) and psoriasis are common skin diseases with a high negative impact
on patients' quality of life. Both diseases are mediated by a pro‐inflammatory infiltrate …

To cite this article: Seike M, Furuya K, Omura M, Hamada‐Watanabe K, Matsushita A, Ohtsu
H. Histamine H4 receptor antagonist ameliorates chronic allergic contact dermatitis induced …

The histamine H4 receptor (H4R) is a promising target for the treatment of pruritus. A clinical
study was conducted to evaluate the safety and efficacy of the H4R antagonist, JNJ …

In this chapter we will first introduce the pathophysiological process of several skin diseases
including allergic dermatitis, a common skin disease, including chronic allergic contact …

The discovery of the histamine H 4 receptor (H 4 R) provided a new avenue for the
exploration of the physiological role of histamine, as well as providing a new drug target for …