[HTML][HTML] SARS-CoV-2 Orphan Gene ORF10 Contributes to More Severe COVID-19 Disease
The orphan gene of SARS-CoV-2, ORF10, is the least studied gene in the virus responsible
for the COVID-19 pandemic. Recent experimentation indicated ORF10 expression …
for the COVID-19 pandemic. Recent experimentation indicated ORF10 expression …
SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression
The virus severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, is the causative
agent of the current COVID-19 pandemic. It possesses a large 30 kilobase (kb) genome that …
agent of the current COVID-19 pandemic. It possesses a large 30 kilobase (kb) genome that …
Dysregulation of intracellular redox homeostasis by the SARS-CoV-2 ORF6 protein
SARS-CoV-2 has evolved several strategies to overcome host cell defenses by inducing cell
injury to favour its replication. Many viruses have been reported to modulate the intracellular …
injury to favour its replication. Many viruses have been reported to modulate the intracellular …
A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication
Y Zhou, Z Chen, S Liu, S Liu, Y Liao, A Du… - … and Targeted Therapy, 2024 - nature.com
The ORF9b protein, derived from the nucleocapsid's open-reading frame in both SARS-CoV
and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by …
and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by …
Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions
Although the accessory proteins are considered non-essential for coronavirus replication,
accumulating evidences demonstrate they are critical to virus-host interaction and …
accumulating evidences demonstrate they are critical to virus-host interaction and …
Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2
L Zinzula - Biochemical and biophysical research communications, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains nine
open reading frames (ORFs) that encode for accessory proteins which, although …
open reading frames (ORFs) that encode for accessory proteins which, although …
Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19
J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …
19-related morbidity and mortality, and the high mutability of the virus. One of the major …
ORF3a-mediated incomplete autophagy facilitates severe acute respiratory syndrome coronavirus-2 replication
Y Qu, X Wang, Y Zhu, W Wang, Y Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent for
the coronavirus disease 2019 (COVID-19) pandemic and there is an urgent need to …
the coronavirus disease 2019 (COVID-19) pandemic and there is an urgent need to …
ORF3a mediated-incomplete autophagy facilitates SARS-CoV-2 replication
Y Qu, X Wang, Y Zhu, Y Wang, X Yang, G Hu, C Liu… - bioRxiv, 2020 - biorxiv.org
ABSTRACT SARS-CoV-2 is the causative agent for the COVID-19 pandemic and there is an
urgent need to understand the cellular response to SARS-CoV-2 infection. Beclin-1 is an …
urgent need to understand the cellular response to SARS-CoV-2 infection. Beclin-1 is an …
SARS-CoV-2 causes mitochondrial dysfunction and mitophagy impairment
C Shang, Z Liu, Y Zhu, J Lu, C Ge, C Zhang… - Frontiers in …, 2022 - frontiersin.org
Mitochondria, which is essential for adequate innate immune response, energy metabolism
and mitochondria reactive oxygen species (ROS) production, might be in the cross fire of …
and mitochondria reactive oxygen species (ROS) production, might be in the cross fire of …