The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication

P Hou, X Wang, H Wang, T Wang, Z Yu, C Xu, Y Zhao… - Autophagy, 2023 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely related
to various cellular aspects associated with autophagy. However, how SARS-CoV-2 …

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts… - Science, 2020 - science.org
INTRODUCTION The emergence of three lethal coronaviruses in< 20 years and the urgency
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies …

SARS-CoV-2 and ORF3a: nonsynonymous mutations, functional domains, and viral pathogenesis

E Issa, G Merhi, B Panossian, T Salloum, S Tokajian - Msystems, 2020 - Am Soc Microbiol
The effect of the rapid accumulation of nonsynonymous mutations on the pathogenesis of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not yet known. The 3a …

SARS-CoV-2 ORF8 protein induces endoplasmic reticulum stress-like responses and facilitates virus replication by triggering calnexin: an unbiased study

X Wang, W Wang, T Wang, J Wang, Y Jiang… - Journal of …, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the viral pathogen
responsible for the worldwide coronavirus disease 2019 (COVID-19) pandemic. The novel …

Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response

Z Cao, H Xia, R Rajsbaum, X Xia, H Wang… - Cellular & molecular …, 2021 - nature.com
Understanding interactions between the host and SARS-CoV-2 is essential for developing
effective vaccines and therapeutics. Here, we report that SARS-CoV-2 usurps the host …

SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functions

S Vinjamuri, L Li, M Bouvier - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. The genome of SARS-
CoV-2 encodes nine accessory proteins that are involved in host-pathogen interaction …

SARS-CoV-2 ORF7b: is a bat virus protein homologue a major cause of COVID-19 symptoms?

ML Fogeron, R Montserret, J Zehnder, MH Nguyen… - BiorXiV, 2021 - biorxiv.org
ORF7b is an accessory protein of SARS-CoV-2, the virus behind the COVID-19 pandemic.
Using cell-free synthesized ORF7b, we experimentally show that ORF7b assembles into …

Decoupling SARS-CoV-2 ORF6 localization and interferon antagonism

HT Wong, V Cheung… - Journal of cell …, 2022 - journals.biologists.com
Like many pathogenic viruses, SARS-CoV-2 must overcome interferon (IFN)-mediated host
defenses for infection establishment. To achieve this, SARS-CoV-2 deploys overlapping …

SARS-CoV-2 accessory protein ORF7b mediates tumor necrosis factor-α-induced apoptosis in cells

R Yang, Q Zhao, J Rao, F Zeng, S Yuan, M Ji… - Frontiers in …, 2021 - frontiersin.org
The accessory proteins of coronaviruses are essential for virus–host interactions and the
modulation of host immune responses. It has been reported that accessory protein ORF3a …

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

Y Ren, T Shu, DI Wu, J Mu, C Wang, M Huang… - Cellular & molecular …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the ongoing
pandemic of Coronavirus Disease 2019. SARS-CoV-2 belongs to the genus …