OBJECTIVE: The purpose of this study was to determine whether microstructural
abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late …

BACKGROUND: The dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex
(ACC) are critical for mood regulation. Alterations in the white matter connections of these …

Objectives: To investigate the disruption of neural circuits in the frontal lobes and limbic
structures in late-life depressed patients compared with healthy controls, and to examine the …

OBJECTIVE: This study tested the hypothesis that microstructural abnormalities in white
matter areas of the brain containing frontostriatal tracts are associated with a low rate of …

Prefrontal impairments have been hypothesized to be most strongly associated with the
cognitive and emotional dysfunction in depression. Recently, white matter microstructural …

Postmortem studies have documented abnormalities in the dorsolateral prefrontal cortex
(dlPFC) in depressed subjects. In this study we used magnetic resonance imaging to test for …

Objective: To evaluate the location and the degree of white matter damage in late-life
depression using diffusion tensor imaging (DTI). Methods: Thirty-one patients with late-life …

Objective: White matter abnormalities may interfere with limbic cortical balance and lead to
chronic depressive syndromes. The authors used diffusion tensor imaging to test the …

BackgroundLate-life depression has been associated with cerebrovascular disease and
especially with ischaemic white matter hyperintensities on magnetic resonance imaging …

Objective Differences in white matter structure measured with diffusion tensor imaging (DTI)
are associated with late-life depression, but results examining how these differences relate …