Development of a poly (lactic-co-glycolic acid) particle vaccine to protect against house dust mite induced allergy
VB Joshi, A Adamcakova-Dodd, X Jing… - The AAPS journal, 2014 - Springer
Poly (lactic-co-glycolic acid)(PLGA) particles carrying antigen and adjuvant is a promising
vaccine system which has been shown to stimulate systemic antigen-specific immune …
vaccine system which has been shown to stimulate systemic antigen-specific immune …
A protective allergy vaccine based on CpG-and protamine-containing PLGA microparticles
JMM Gómez, S Fischer, N Csaba, TM Kündig… - Pharmaceutical …, 2007 - Springer
Purpose Allergen-specific immunotherapy (SIT) requires dozens of subcutaneous injections
over 3 to 5 years in order to control IgE-mediated hypersensitivity, which is a T-helper 2 …
over 3 to 5 years in order to control IgE-mediated hypersensitivity, which is a T-helper 2 …
A promising CpG adjuvant-loaded nanoparticle-based vaccine for treatment of dust mite allergies
AK Salem - Immunotherapy, 2014 - Future Medicine
Editorial Salem that promote Th1-biased allergen specific immune responses to reduce lung
damage linked with exposure to allergen [9]. Unmethylated cytosine-phosphateguanine …
damage linked with exposure to allergen [9]. Unmethylated cytosine-phosphateguanine …
Intranasal vaccination with poly(lactide‐co‐glycolide) microparticles containing a peptide T of Ole e 1 prevents mice against sensitization
EG Marazuela, N Prado, E Moro… - Clinical & …, 2008 - Wiley Online Library
Background Biodegradable microparticles, in particular poly (lactide‐co‐glycolide)(PLGA),
have been shown as potential delivery vehicles for intranasal (in) vaccines in animal …
have been shown as potential delivery vehicles for intranasal (in) vaccines in animal …
Modulation of allergic responses in mice by using biodegradable poly (lactide-co-glycolide) microspheres
S Jilek, E Walter, HP Merkle, B Corthésy - Journal of allergy and clinical …, 2004 - Elsevier
BACKGROUND: Biodegradable poly (lactide-co-glycolide)(PLGA) microspheres are a
promising carrier for vaccine delivery capable of maturing antigen-presenting cells to …
promising carrier for vaccine delivery capable of maturing antigen-presenting cells to …
Preparation and characterization of poly-(D, L-lactide-co-glycolide) and poly-(L-lactic acid) microspheres with entrapped pneumotropic bacterial antigens
N Kofler, C Ruedl, J Klima, H Recheis, G Böck… - Journal of …, 1996 - Elsevier
Poly-(lactide-co-glycolide) microspheres with entrapped antigen have shown considerable
promise as controlled release vaccines. To enhance the immunomodulatory effect of LW …
promise as controlled release vaccines. To enhance the immunomodulatory effect of LW …
Poly-(lactic-co-glycolic-acid)-based particulate vaccines: particle uptake by dendritic cells is a key parameter for immune activation
Poly (lactic-co-glycolic acid)(PLGA) particles have been extensively studied as
biodegradable delivery system to improve the potency and safety of protein-based vaccines …
biodegradable delivery system to improve the potency and safety of protein-based vaccines …
Down-regulation of Th2 immune responses by sublingual administration of poly (lactic-co-glycolic) acid (PLGA)-encapsulated allergen in BALB/c mice
The goal of this study was to investigate whether poly (lactic-co-glycolic) acid (PLGA)
nanoparticles could enhance sublingual immunotherapy (SLIT) efficacy. BALB/c mice …
nanoparticles could enhance sublingual immunotherapy (SLIT) efficacy. BALB/c mice …
Oral Immunization with Poly-(D,L-Lactide-Co-Glycolide) and Poly-(L-Lactic Acid) Microspheres Containing Pneumotropic Bacterial Antigens
N Kofler, C Ruedl, C Rieser, G Wick… - International archives of …, 1997 - karger.com
Encouraged by recent findings showing the usefulness of nonreplicating antigen delivery
systems in the induction of mucosal immune responses, we investigated microspheres as a …
systems in the induction of mucosal immune responses, we investigated microspheres as a …
In vivo uptake of an experimental microencapsulated diphtheria vaccine following sub-cutaneous immunisation
Previous studies demonstrated in vitro phagocytosis of poly (lactide-co-glycolide)(PLGA)
microspheres (MS) by macrophages and dendritic cells and the biodistribution of fluorescent …
microspheres (MS) by macrophages and dendritic cells and the biodistribution of fluorescent …