Mucosal adjuvants for influenza virus-like particle vaccine

FS Quan, EJ Ko, YM Kwon, KH Joo… - Viral …, 2013 - liebertpub.com
To find an effective mucosal adjuvant for influenza virus-like particles (VLPs), we compared
the effects of known adjuvants Alum, CpG DNA, monophosphoryl lipid A (MPL), poly IC …

Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre-and postsensitization

CB Smarr, WT Yap, TP Neef… - Proceedings of the …, 2016 - National Acad Sciences
Specific immunotherapy (SIT) is the most widely used treatment for allergic diseases that
directly targets the T helper 2 (Th2) bias underlying allergy. However, the most widespread …

Mucosal immunization with recombinant influenza hemagglutinin protein and poly gamma-glutamate/chitosan nanoparticles induces protection against highly …

HJ Moon, JS Lee, MR Talactac, MYE Chowdhury… - Veterinary …, 2012 - Elsevier
Intranasal administration of recombinant influenza hemagglutinin (rHA) antigen or
inactivated virus with nanoparticles (NPs) composed of poly-γ-glutamic acid (γ-PGA) and …

Biodegradable poly (DL-lactide glycolide) microparticles as a vehicle for allergen-specific vaccines: a study performed with Ole e 1, the main allergen of olive pollen

E Batanero, P Barral, M Villalba, R Rodrı́guez - Journal of immunological …, 2002 - Elsevier
Ole e 1, the main allergen of the olive pollen, was entrapped in poly (dl-lactide glycolide)
microparticles by a solvent evaporation double emulsion technique. The physical properties …

Soybean agglutinin coated PLA particles entrapping candidate vaccines induces enhanced primary and sustained secondary antibody response from single point …

RK Gupta, DG Goswami, RR Singh, A Surolia… - European journal of …, 2012 - Elsevier
Polylactide (PLA) polymer particles entrapping diphtheria toxoid (DT) or tetanus toxoid (TT)
were formulated with surface coatings of soybean agglutinin to have dendritic cells (DCs) …

A dendritic cells-targeting nano-vaccine by coupling polylactic-Co-glycolic acid-encapsulated allergen with mannan induces regulatory T cells

H Wen, L Qu, Y Zhang, B Xu, S Ling, X Liu… - … Archives of Allergy and …, 2021 - karger.com
Background: The efficacy of allergen-specific immunotherapy (AIT) is mainly depended on
the tolerogenic immune responses elicited. Properly conjugated nano-vaccine has the …

Biodegradable particles as vaccine delivery systems: size matters

VB Joshi, SM Geary, AK Salem - The AAPS journal, 2013 - Springer
Abstract Poly (lactide-co-glycolide)(PLGA) particles have strong potential as antigen delivery
systems. The size of PLGA particles used to vaccinate mice can affect the magnitude of the …

Nasal vaccination with poly (β-amino ester)-poly (d, l-lactide-co-glycolide) hybrid nanoparticles

G Sinani, M Sessevmez, MK Gök, S Özgümüş… - International Journal of …, 2017 - Elsevier
Mucosal vaccination stimulates both mucosal and systemic immunity. However, mucosal
applications of vaccine antigens in their free form generally result in poor systemic immune …

Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease

VL Herrmann, C Hartmayer, O Planz… - Journal of controlled …, 2015 - Elsevier
Current influenza virus vaccines aim to elicit antibodies directed toward viral surface
glycoproteins, which however are prone to antigenic drift. Cytotoxic T lymphocytes (CTLs) …

Characterization of immunogenicity of avian influenza antigens encapsulated in PLGA nanoparticles following mucosal and subcutaneous delivery in chickens

TN Alkie, A Yitbarek, K Taha-Abdelaziz, J Astill… - PLoS …, 2018 - journals.plos.org
Mucosal vaccine delivery systems have paramount importance for the induction of mucosal
antibody responses. Two studies were conducted to evaluate immunogenicity of inactivated …