Microparticle-based vaccine delivery systems are known to promote enhanced immune
responses to protein antigens and can elicit TH 1-biased responses when used in …

Background Second generation therapeutic vaccines based upon recombinant allergens or
natural extracts, potentially formulated in vector systems or adjuvants, are being developed …

Porous poly (l-lactic acid)(PLA) and poly (lactic-co-glycolic acid)(PLGA) nanoparticles were
tested for pulmonary delivery of hepatitis B vaccine. In particular, the effects of particle size …

T-cells play a critical role in resistance to malaria, not only because they function as helper
cells for an antibody response, but also because they serve as effector cells. Such cellular …

Background: CpG oligodeoxynucleotides (CpG ODNs) are reported to protect against airway
eosinophilia and hyperresponsiveness in animal models of asthma. However, little is known …

In this study surface coated poly-(ɛ-caprolactone)(PCL) nanoparticles with chitosan (CS)
were developed as a carrier system for nasal immunization using recombinant Influenza A …

Introduction: Many human pathogens cause respiratory illness by colonizing and invading
the respiratory mucosal surfaces. Preventing infection at local sites via mucosally active …

Allergic asthma caused by house dust mite (HDM) is becoming a public health problem.
Specific immunotherapy is considered to be the only curative treatment, but it is always …

Purpose. Spray-dried lipid-based microparticles (SDLM) serve as a platform for delivery of a
wide variety of compounds including peptides, proteins, and vaccines to the respiratory …

Particle exposure has traditionally been monitored as mass concentration of PM10 (particles
with an aerodynamic diameter less than 10 μm), more recently also as PM2. 5. The mass …