This article presents a personal viewpoint of the shortcoming of conventional hemodynamic
resuscitation procedures in achieving organ perfusion and tissue oxygenation following …

Oxygen delivery to cells is the basic prerequisite of life. Within the human body, an
ingenious oxygen delivery system, comprising steps of convection and diffusion from the …

Background The availability of handheld, noninvasive sublingual video-microscopes allows
for visualization of the microcirculation in critically ill patients. Recent studies demonstrate …

This review examines experimental evidence that the microvascular dysfunction that occurs
early in sepsis is the critical first stage in tissue hypoxia and organ failure. A functional …

Introduction The introduction of orthogonal polarization spectral (OPS) imaging in clinical
research has elucidated new perspectives on the role of microcirculatory flow abnormalities …

The goal of hemodynamic resuscitation is to optimize the microcirculation of organs to meet
their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the …

Background We sought to determine the effects of alternative resuscitation strategies on
microcirculatory perfusion and examine any association between microcirculatory perfusion …

Microcirculatory dysfunction plays a pivotal role in the development of the clinical
manifestations of severe sepsis. Prior to the advent of new imaging technologies, clinicians …

A growing body of evidence exists associating depressed microcirculatory function and
morbidity and mortality in a wide array of clinical scenarios. It has been suggested that …

Fluid imbalance can arise due to hypovolemia, normovolemia with maldistribution of fluid,
and hypervolemia. Trauma is among the most frequent causes of hypovolemia, with its often …