The aim of this investigation was to assess the role that NO plays in the antinociceptive
activity of tramadol using a rat model of neuropathic pain. Thirty male Wistar rats weighing …

Aims: The involvement of NO modulation in tramadol's mechanism of action is demonstrated
indirectly by the alteration of the effect with the use of nitric oxide synthase inhibitor nitroG-L …

It has been considered that tramadol, a centrally acting analgesic, shows its effect via
opiatergic, noradrenergic, and serotonergic systems. It has a low affinity for opioid receptors …

Tramadol, an analgesic classified as an “atypical opioid”, exhibits both opioid and non-
opioid mechanisms of action. This study aimed to explore these mechanisms, specifically …

Amaç: Tek başına veya birlikte sistemik olarak verilen tramadol ve gabapentinin farelerde
akut ağrıda muhtemel antinosiseptif etklerini araştırmaktır. Gereç ve Yöntem: Hayvan Etik …

The analgesic agent tramadol has a potent antinociceptive effect in arthritic rats. In the
present study, the actions of the selective α 2-adrenoceptor antagonists yohimbine and …

Tramadol is a widely‐used analgesic for pre‐and post‐operative pain which has a different
pharmacological profile to that of classical opioids, since it does not induce respiratory …

Objective (s): The relationship between tramadol, as an antinociceptive drug, and locus
coeruleus (LC), the main noradrenergic nucleus of the brain that affects regulation and …

Objective: To study a possible interaction between tramadol, an opioid analgesic and
amlodipine, a dihydropyridine calcium channel blocker with proposed antinociceptive …

Tramadol is a centrally acting analgesic drug able to prevent nociceptor sensitization when
administered into the temporomandibular joint (TMJ) of rats. The mechanism underlying the …