The limited success of current treatments for most advanced common malignancies
highlights the importance of cancer prevention. Clinical trials on cyclooxygenase (COX) …

Chemoprevention of colorectal cancer is a promising science that has particular importance
due to the limited success of current treatments for most advanced common malignancies …

Colorectal cancer (CRC) leads to approximately 550,000 annual deaths worldwide and is
thus a major public health concern [1]. Once an individual is diagnosed with CRC, the …

Colorectal cancer is a major cause of morbidity and mortality accounting for an estimated
550,000 deaths annually worldwide. Colonic neoplasia develops in a stepwise fashion …

Cancer is predicted to become the leading cause of death–surpassing heart disease–by the
end of this decade. Colorectal cancer is a major health concern, with more than 1,000,000 …

Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …

Aspirin is the best chemoprevention agent for colorectal cancer risk reduction despite the
fact that the evidence for a decrease in mortality is weak. The cyclooxygenase-2 selective …

Two events in the last decade have set the stage for the large-scale clinical testing of
chemopreventive agents for colorectal cancer in people at low to moderate risk for this …

Colorectal cancer (CRC) is one of the most common neoplasia in Western countries and the
second leading cause of cancer-related death. The vast majority of cases belong to sporadic …

Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received
considerable attention due to its role in human cancers. Observational and randomized …