Carcinogenesis results from the long-term accumulation of genetic and epigenetic
aberrations at the molecular level, which are under constant selection pressure for growth …

The existing epidemiologic literature was comprehensively reviewed to retrieve all
epidemiologic studies (case control and cohort studies) that examined exposure to …

Abstract Cyclooxygenase 2 (COX-2), also called prostaglandin endoperoxide synthase 2, is
involved in colorectal tumor development. This review deals with particular questions raised …

Currently, combination chemotherapy represents the standard of care treatment for patients
with metastatic colorectal cancer in the United States. Despite recent improvements with the …

The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin
(PG) biosynthesis. Nonselective non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the …

▪ Abstract Disease prevention is one area that both public and governmental agencies
strongly support owing to its potential for an improved lifestyle and a reduction in health care …

Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …

Metabolites of arachidonic acid participate in normal growth responses and in aberrant
cellular growth and proliferation, including carcinogenesis. The key step in the conversion of …

This chapter briefly summarizes the current knowledge about the role of nonsteroidal anti-
inflammatory drugs (NSAIDs), specially focusing on those selective for cyclooxygenase …

BACKGROUND Aspirin therapy is accepted widely for secondary prevention in patients with
documented cardiovascular disease, but there is a growing trend among healthy individuals …