T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …

In studies of immune aging, naive T cells frequently take center stage. Describing the
complexity of the human naive T cell repertoire remains a daunting task; however, emerging …

As the thymus involutes during aging, the T‐cell pool has to be maintained by the periodic
expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of …

Acquired immune function shows recognizable changes over time with organismal aging.
These changes include T-cell dysfunction, which may underlie diminished resistance to …

Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …

The adaptive immune system has the enormous challenge to protect the host through the
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …

As humans live longer, a central concern is to find ways to maintain their health as they age.
Immunity declines during ageing, as shown by the increased susceptibility to infection by …

The aged adaptive immune system is characterized by progressive dysfunction as well as
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …

The immune system exhibits profound age-related changes, collectively termed
immunosenescence. The most visible of these is the decline in protective immunity, which …

With increasing age, the ability of the immune system to protect against new antigenic
challenges or to control chronic infections erodes. Decline in thymic function and cumulating …