Introduction: Selectins mediate tethering and rolling of leukocytes to the vascular
endothelium, the first adhesive step in the recruitment of immune cells to inflamed tissues …

Leukocyte migration into the tissues represents a key process in the pathogenesis of
inflammatory diseases. Data obtained in clinical trials have convincingly shown that …

Selectins are multifunctional adhesion molecules that mediate the initial interactions
between circulating leukocytes and cells of the endothelium. First identified over a decade …

Selectins mediate tethering and rolling of leukocytes to the vascular endothelium, the first
adhesive step in the recruitment of immune cells to inflamed tissues. Thus, selectins play a …

Selectins are carbohydrate-binding molecules that bind to fucosylated and sialylated
glycoprotein ligands, and are found on endothelial cells, leukocytes and platelets. They are …

Tissue inflammation is a finely regulated process that controls wound healing and allows the
clearance of damaged cells, pathogens and irritants. However, excessive or uncontrolled …

Selectins are multi-functional adhesion molecules that mediate the initial interactions
between circulating leukocytes and the endothelium. First identified over a decade ago …

Inhibition of leukocyte migration into target organs has long been an attractive, though
challenging, basis for anti-inflammatory strategies. However, to date, the manipulation of …

Importance of the field: Selectins play a significant and well-documented role in
inflammation and immune response. They initiate tethering and rolling of blood borne …

Leukocyte emigration is essential in both lymphocyte homing, as a central part of immune
surveillance, and in leukocyte invasion at sites of inflammation. The emigration of leukocytes …