Vestweber, Dietmar, and James E. Blanks. Mechanisms That Regulate the Function of the
Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999.—Selectins are a family of …

Selectins belong to a group of adhesion molecules that fulfill an essential role in immune
and inflammatory responses and tissue healing. Selectins are glycoproteins that decode the …

Cell adhesion molecules play a key role in different physiological and pathological
phenomena. Selectins comprise a family of three members (E-, P-, and L-selectin) that are …

Inflammation and cancer metastasis are associated with extravasation of leukocytes or
tumor cells from blood into tissue. Such movement is believed to follow a coordinated and …

Selectin enzymes are glycoproteins and are an important adhesion molecule in the
mammalian immune system, especially in the inflammatory response and the healing …

The selectins are a family of cell-adhesion proteins that mediate the early stages of
leukocyte recruitment from the blood stream to sites of tissue damage through recognition of …

Publisher Summary This chapter provides a synoptic review of several investigations that
have converged and synergistically interacted to develop clinically useful anti-inflammatory …

The migration of leukocytes from the blood stream to sites of infection is a key event in
cellular immune response, mediated by multiple types of molecules including several …

Selectin binding is the first step in extravasation of leukocytes through the endothelium.
Infiltration of leukocytes is a hallmark of an inflammatory response. Blockade of selectin …

The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on
vascular surfaces, the first adhesive step during inflammation and immune surveillance …