Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis

RA Furtado, BR Oliveira, LR Silva… - European Journal of …, 2015 - journals.lww.com
Rosmarinic acid (RA) is a polyphenolic compound that shows a number of interesting
biological activities, such as antiapoptotic, antifibrotic, antioxidant, hepatoprotective …

Biochemical and molecular mechanisms underlying the chemopreventive efficacy of rosmarinic acid in a rat colon cancer

K Venkatachalam, S Gunasekaran… - European Journal of …, 2016 - Elsevier
To shed light on colon cancer chemoprevention, natural phytochemicals attract researchers
by virtue of their beneficial biological effects. The chemopreventive potential of rosmarinic …

Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1, 2-dimethylhydrazine induced rat colon carcinogenesis

V Karthikkumar, G Sivagami, R Vinothkumar… - Environmental …, 2012 - Elsevier
Colorectal cancer is one of the leading causes of cancer related deaths in Western countries
and is becoming increasingly common in Asia. Rosmarinic acid (RA), one of the major …

The effect of rosmarinic acid on 1, 2-dimethylhydrazine induced colon carcinogenesis

K Venkatachalam, S Gunasekaran… - Experimental and …, 2013 - Elsevier
This study was carried out to investigate the chemopreventive potential of rosmarinic acid
(RA) against 1, 2-dimethylhydrazine (DMH) induced rat colon carcinogenesis by evaluating …

Chemopreventive effect of trans -resveratrol - a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced …

M Sengottuvelan, P Viswanathan, N Nalini - Carcinogenesis, 2006 - academic.oup.com
Prevention of cancer remains a primary need and new chemopreventive agents must be
developed for this purpose. Towards this goal, a chemoprevention study was conducted to …

Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats

V Karthikkumar, G Sivagami… - Journal of basic and …, 2015 - degruyter.com
Background: Colon cancer is one of the most common cancers in both men and women. The
present study is an effort to unravel the anticarcinogenic effects of rosmarinic acid (RA) in 1 …

DNA damage and aberrant crypt foci as putative biomarkers to evaluate the chemopreventive effect of annatto (Bixa orellana L.) in rat colon carcinogenesis

AR Agner, AP Bazo, LR Ribeiro… - Mutation Research/Genetic …, 2005 - Elsevier
Chemoprevention opens new perspectives in the prevention of cancer and other
degenerative diseases. Use of target-organ biological models at the histological and genetic …

Protective effects of rosmarinic acid against azoxymethane‐induced colorectal cancer in rats

N Ilhan, I Bektas, S Susam… - Journal of Biochemical …, 2022 - Wiley Online Library
Colorectal cancer (CRC) incidence is increasing gradually and has been become one of the
most common cancers worldwide. Hence, it is important to discover cheap, naturally …

Dietary intake of rosmarinic acid by ApcMin mice, a model of colorectal carcinogenesis: levels of parent agent in the target tissue and effect on adenoma …

A Karmokar, TH Marczylo, H Cai… - Molecular nutrition & …, 2012 - Wiley Online Library
Scope Rosmarinic acid (RA), a constituent of culinary herbs is considered to possess cancer
chemopreventive properties. It has been shown to inhibit the development of cancer in …

Resveratrol ameliorates DNA damage, prooxidant and antioxidant imbalance in 1, 2-dimethylhydrazine induced rat colon carcinogenesis

M Sengottuvelan, K Deeptha, N Nalini - Chemico-biological interactions, 2009 - Elsevier
Colorectal cancer is one of the most common internal malignancies in Western society.
Currently oxidative stress has been increasingly postulated as a major contributor to …