The production of hyperglycemia-induced mitochondrial reactive oxygen species (mtROS) is
a key event in the development of diabetic complications. Because resveratrol, a naturally …

Rationale: Extracellular vesicles, including microvesicles, are increasingly recognized as
important mediators in cardiovascular disease. The cargo and surface proteins they carry …

The mechanisms by which reactive species (RS) participate in the development of
atherosclerosis remain incompletely understood. The present study was designed to test the …

Previous studies have shown that the aging vascular system undergoes pro-atherogenic
phenotypic changes, including increased oxidative stress and a pro-inflammatory shift in …

The prevalence of cardiovascular diseases is significantly increased in the older population.
Risk factors and predictors of future cardiovascular events such as hypertension …

Rationale: DNA damage is present in both genomic and mitochondrial DNA in
atherosclerosis. However, whether DNA damage itself promotes atherosclerosis, or is simply …

Diastolic dysfunction (DD) underlies heart failure with preserved ejection fraction (HFpEF), a
clinical syndrome associated with aging that is becoming more prevalent. Despite extensive …

A decline in mitochondrial redox homeostasis has been associated with the development of
a wide range of inflammatory-related diseases. Continue discoveries demonstrate that …

Cardiovascular diseases (CVD) are the leading cause of death worldwide and aging is the
primary risk factor for CVD. The development of vascular dysfunction, including endothelial …

Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes,
and can accelerate diabetes-related microvascular and macrovascular complications by …