Mitochondria are organelles with highly dynamic ultrastructure maintained by flexible fusion
and fission rates governed by Guanosine Triphosphatases (GTPases) dependent proteins …

Reactive oxygen species (ROS) are key mediators in signal transduction of angiotensin II
(Ang II). However, roles of vascular mitochondria, a major intracellular ROS source, in …

Inflammation is associated with the release of soluble mediators that drive cellular activation
and migration of inflammatory leukocytes to the site of injury, together with endothelial …

Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells,
which can generate and sequester toxic reactive oxygen species (ROS) in response to …

Nutritional supplements, calorie restriction, and life style change are the most effective
preventive strategies to improve mitochondrial function and reduce mitochondrial oxidative …

Functional impairment of endothelial activity (endothelial dysfunction) precedes the
development of cardiovascular diseases (CVD). This condition is a result of a reduced …

Abstract Aims: Angiotensin II (AngII)-induced superoxide (O2•−) production by the NADPH
oxidases and mitochondria has been implicated in the pathogenesis of endothelial …

Pathways that regulate mitochondrial biogenesis are potential therapeutic targets for the
amelioration of endothelial dysfunction and vascular disease. Resveratrol was shown to …

Vascular mitochondria constantly integrate signals from environment and respond
accordingly to match vascular function to metabolic requirements of the organ tissues, while …

Arterial remodeling is a common pathological basis of cardiovascular diseases such as
atherosclerosis, vascular restenosis, hypertension, pulmonary hypertension, aortic …