We have tested the hypothesis that a high density of negative charge at the luminal mouth of
the RyR2 pore plays a pivotal role in the high cation conductance and limited selectivity …

Using the bacterial K+ channel KcsA as a template, we constructed models of the pore
region of the cardiac ryanodine receptor channel (RyR2) monomer and tetramer …

Anomalies in the permeation properties of the cardiac RyR channel reconstituted into bilayer
lipid membranes were investigated systematically. We tested the presence of the anomalous …

Publisher Summary The intracellular Ca 2+-release channel referred to as the “ryanodine
receptor (RyR)” is a key factor in a plethora of biological and pathophysiological processes …

Introduction 3. The physiological role of the ryanodine receptor channel 4. The ion handling
properties of RyR 4.1. Physiologically relevant cations 4.2. Permeation and block by organic …

The homotetrameric structure of the ryanodine-sensitive intracellular calcium (Ca 2+)
release channel (ryanodine receptor (RyR)) suggests that the four RyR subunits either …

The ryanodine receptor (RyR) ion channel releases Ca 2+ from intracellular stores by
conducting Ca 2+ but also by recruiting neighboring RyRs to open, as RyRs are activated by …

We have investigated the influence of transmembrane holding potential on the kinetics of
interaction of a cationic ryanoid, 8β-amino-9α-hydroxyryanodine, with individual ryanodine …

Three ryanodine receptor (RyR) isoforms, RyR1, RyR2, and RyR3, are expressed in
mammalian tissues. It is unclear whether RyR isoforms are capable of forming heteromeric …

Cardiac ryanodine receptors (RYR2s) infrequently exhibit coupled gating that is manifested
by synchronous opening and closing. To better characterize this phenomenon, we …