Osteoarthritis (OA) is associated with cartilage breakdown, brought about by ADAMTS-5
mediated aggrecan degradation followed by MMP-derived aggrecan and type II collagen …

Degradation of proteoglycan is the key early event in the development of osteoarthritis (OA).
The aggrecanase ADAMTS-5 has been identified as the major enzyme responsible for the …

Objective Links between pain and joint degradation are poorly understood. We investigated
the role of activation of Toll-like receptors (TLR) by cartilage metabolites in initiating and …

Tumor necrosis factor (TNF)-α and a disintegrin and metalloproteinase with thrombospondin
motifs 4 (ADAMTS-4) are important in osteoarthritis (OA) cartilage degradation. In the …

There are currently no approved disease-modifying osteoarthritis (OA) drugs (DMOADs).
The aggrecanase ADAMTS-5 is key in the degradation of human aggrecan (AGC), a …

Objective A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a
key enzyme in degradation of cartilage in osteoarthritis (OA). We report the pharmacological …

Objective To examine the expression of ADAMTS-7 during the progression of osteoarthritis
(OA), defining its role in the pathogenesis of OA, and elucidating the molecular events …

Objective Recent published studies have shown that cartilage from ADAMTS‐5–knockout
mice, but not ADAMTS‐4–or ADAMTS‐1–knockout mice, is significantly protected from …

The metalloprotease ADAMTS-5 is considered a potential target for the treatment of
osteoarthritis. To identify selective inhibitors of ADAMTS-5, we employed encoded library …

Osteoarthritis (OA) is the most common degenerative joint disease characterized by
enzymatic degradation of the cartilage extracellular matrix (ECM) causing joint pain and …