There is compelling evidence that senescent cells, through the senescence-associated
secretory phenotype (SASP), can promote malignant transformation and invasion …

Cellular senescence has emerged as a potent tumor suppressor mechanism in numerous
human neoplasias. Senescent cells secrete a distinct set of factors, collectively termed the …

Senescent cells produce a Senescence‐Associated Secretory Phenotype (SASP) that
involves factors with diverse and sometimes contradictory activities. One key SASP factor …

Inflammation underlies most age-related diseases, including cancer, but the etiology is
poorly understood. One proposed factor is the presence of senescent cells, which increase …

Cellular senescence, a state of sustained cell cycle arrest, has been identified as an
important anti-tumor barrier. Senescent cells secrete various growth factors and cytokines …

Senescence is a form of cell cycle arrest induced by stress such as DNA damage and
oncogenes. However, while arrested, senescent cells secrete a variety of proteins …

Abstract Cutaneous Squamous Cell Carcinoma (cSCC) is the second most common type of
non-melanoma skin cancer in white-skinned populations. cSCC is associated with sun …

Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells
implement a complex pro-inflammatory response termed the senescence-associated …

Since the removal of senescent cells in model organisms has been linked to rejuvenation
and increased lifespan, senotherapies have emerged to target senescent cells for death. In …

Cellular senescence, a state of stable cell cycle arrest in response to cellular stress, is an
indispensable mechanism to counter tumorigenesis by halting the proliferation of damaged …