On acquisition of an oncogenic mutation, primary human and mouse cells can enter
oncogene-induced senescence (OIS). OIS is characterized by a stable proliferation arrest …

Cellular senescence entails an irreversible growth arrest that evolved in part to prevent
cancer. Paradoxically, senescent cells secrete proinflammatory and growth-stimulatory …

To cope with the frequent exposure to carcinogenic UV B (UVB) wavelengths found in
sunlight, keratinocytes have acquired extensive protective measures to handle UVB-induced …

Immune checkpoint blockade (ICB) therapy is a central pillar of melanoma treatment leading
to durable response rates. Important mechanisms of action of ICB therapy include …

Senescent cells develop a senescence-associated secretory phenotype (SASP). The factors
secreted by cells with a SASP have multiple biological functions that are mediated in an …

Oral cancers are predominantly oral squamous cell carcinomas (OSCCs) derived from
keratinocytes, and there is now very detailed knowledge of the genetics and molecular …

Skin is one of the most exposed organs to external stress. Namely, UV rays are the most
harmful stress that could induce important damage leading to skin aging and cancers. At the …

Cellular senescence is a state of irreversible cellular growth arrest accompanied by distinct
changes in gene expression and the acquisition of a complex proinflammatory secretory …

The appropriate response of human keratinocytes to ultraviolet-B (UVB) is dependent on the
activation status of the insulin-like growth factor 1 (IGF-1) receptor. Keratinocytes grown in …

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at
risk for malignant transformation. However, accumulating evidence shows that senescent …