Senescent cells secrete a combination of factors collectively known as the senescence-
associated secretory phenotype (SASP). The SASP reinforces senescence and activates an …

There is evidence that one critically short telomere may be recognized as DNA damage and,
as a consequence, induce a p53/p21WAF-and pl6INK4A-dependent G1 cell cycle …

Therapy-induced cellular senescence is a state of stable growth arrest induced by common
cancer treatments such as chemotherapy and radiation. In an oncogenic context, therapy …

Cellular senescence is a state of irreversible growth arrest that can be triggered by multiple
mechanisms, including telomere shortening, the epigenetic derepression of the INK4α/ARF …

During malignant transformation in skin, epidermal keratinocytes (KCs) frequently acquire
the capacity to by-pass cellular senescence, a response that normally limits their …

Interferon (IFN)-β inhibits cell proliferation and affects cell cycle in keratinocytes transformed
by both mucosal high risk Human Papilloma Virus (HPV) and cutaneous HPV E6 and E7 …

Cellular senescence is a state of irreversible cellular growth arrest accompanied by distinct
changes in gene expression and the acquisition of a complex proinflammatory secretory …

Senescent cells accumulate in aged tissue and are causally linked to age-associated tissue
degeneration. These non-dividing, metabolically active cells are highly secretory and alter …

Cellular senescence, which is associated with aging, is a process by which cells enter a
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …

Cellular senescence is the state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli and has therefore long been considered to suppress …