Uncontrolled or non-resolving inflammation underpins a range of disease states including
rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Hypoxia is a …

Uncontrolled inflammation underpins a diverse range of diseases where effective therapy
remains an unmet clinical need. Hypoxia is a prominent feature of the inflammatory …

Hypoxia and inflammation are frequently co-incidental features of the tissue
microenvironment in a wide range of inflammatory diseases. While the impact of hypoxia on …

Sites of inflammation are defined by significant changes in metabolic activity. Recent studies
have suggested that O2 metabolism and hypoxia play a prominent role in inflammation so …

Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to
inadequate tissue oxygenation is regulated by hypoxia-inducible factors (HIFs). HIFs are key …

Sites of inflammation are characterized by significant changes in metabolic activity. Shifts in
energy supply and demand can result in diminished delivery and/or avai lability of oxygen …

Leukocytes recruited to infected, damaged, or inflamed tissues during an immune response
must adapt to oxygen levels much lower than those in the circulation. Hypoxia inducible …

Autoimmune disorders are a complicated and varied group of diseases arising from
inappropriate immune responses. Recent studies have demonstrated that ongoing …

Recent years have witnessed an emergence of interest in understanding metabolic changes
associated with immune responses, termed immunometabolism. As oxygen is central to all …

Highlights•Hypoxia is a prominent feature in inflamed tissues.•The HIF pathway is a potential
therapeutic target in inflammation.•Hydroxylase inhibition is anti-inflammatory in models of …