The surge in interest in chemokines is explained by the recognition that numerous aspects
of immunity are intimately related to leukocyte traffic. Chemokines are leukocyte attractants …

Physiological leukocyte homing and extravasation of leukocytes during inflammatory
processes is directed by a number of proteins including adhesion molecules, proteases …

This review describes recent breakthroughs in our understanding of the roles played by
chemokines in lymphocyte trafficking. These include the first demonstration that chemokines …

The migration of leukocytes in immune surveillance and inflammation is largely determined
by their response to chemokines. While the chemokine specificities and expression patterns …

Leukocyte recruitment from the circulation into inflammatory tissues requires a series of
soluble and cell-bound signals between the responding leukocyte and vascular endothelial …

Chemokine receptors play a key role in directing the migration of inflammatory cells into
various injured or infected organs. However, migration of inflammatory cells into tissues can …

Most, if not all, chemokines bind to seven transmembrane spanning G protein-coupled
receptors and activate cellular migration. Stimulated chemokine expression is essential for …

Motility is a hallmark of leukocytes, and breakdown in the control of migration contributes to
many inflammatory diseases. Chemotactic migration of leukocytes largely depends on …

In contrast to the remarkable chemokine responses of phagocytes and monocytes that were
documented early on, lymphocytes have been considered for a long time to be poor targets …

The location of leukocytes in different microenvironments is intimately connected to their
function and, in the case of leukocyte precursors, to the executed differentiation and …