KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels

N Hoshi, H Takahashi, M Shahidullah… - Journal of Biological …, 1998 - ASBMB
Cerebellar granule neurons possess a non-inactivating K+ current, which controls resting
membrane potentials and modulates the firing rate by means of muscarinic agonists. kcr1 …

Elevation of intracellular Ca2+ modulates A‐currents in rat cerebellar granule neurons

X Wang, J Bao, XM Zeng, Z Liu… - Journal of neuroscience …, 2005 - Wiley Online Library
In the brain, the transient‐inactivating voltage‐gated potassium channel currents (called IK
(A) or A‐currents) are activated at subthreshold membrane potentials to control the …

Characterization of four types of background potassium channels in rat cerebellar granule neurons

J Han, J Truell, C Gnatenco, D Kim - The Journal of Physiology, 2002 - Wiley Online Library
Cerebellar granule neurons express a standing outward (background) K+ current (IK, SO)
that regulates the resting membrane potential and cell excitability. As several tandem‐pore …

A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons

JA Millar, L Barratt, AP Southan… - Proceedings of the …, 2000 - National Acad Sciences
Cerebellar granule neurons (CGNs) are one of the most populous cells in the mammalian
brain. They express an outwardly rectifying potassium current, termed a “standing-outward” …

What are the roles of the many different types of potassium channel expressed in cerebellar granule cells?

A Mathie, CE Clarke, KM Ranatunga, EL Veale - The Cerebellum, 2003 - Springer
Potassium (K) channels have a key role in the regulation of neuronal excitability. Over a
hundred different subunits encoding distinct K channel subtypes have been identified so far …

Regulation of Ca2+-dependent K+ channel expression in rat cerebellum during postnatal development

YL Muller, R Reitstetter, AJ Yool - Journal of Neuroscience, 1998 - Soc Neuroscience
Potassium channels govern duration and frequency of excitable membrane events and may
regulate signals that are important in neuronal development. This study assesses the …

K+-dependent cerebellar granule neuron apoptosis: role of TASK leak K+ channels

I Lauritzen, M Zanzouri, E Honoré, F Duprat… - Journal of Biological …, 2003 - ASBMB
Rat mature cerebellar granule, unlike hippocampal neurons, die by apoptosis when cultured
in a medium containing a physiological concentration of K+ but survive under high external …

Ternary Kv4.2 channels recapitulate voltage‐dependent inactivation kinetics of A‐type K+ channels in cerebellar granule neurons

Y Amarillo, JA De Santiago‐Castillo… - The Journal of …, 2008 - Wiley Online Library
Kv4 channels mediate most of the somatodendritic subthreshold operating A‐type current
(ISA) in neurons. This current plays essential roles in the regulation of spike timing, repetitive …

Identification of the Kv2. 1 K+ channel as a major component of the delayed rectifier K+ current in rat hippocampal neurons

H Murakoshi, JS Trimmer - Journal of Neuroscience, 1999 - Soc Neuroscience
Molecular cloning studies have revealed the existence of a large family of voltage-gated K+
channel genes expressed in mammalian brain. This molecular diversity underlies the vast …

Phosphorylation by protein kinase A of RCK1 K+ channels expressed in Xenopus oocytes

T Ivanina, T Perets, WB Thornhill, G Levin, N Dascal… - Biochemistry, 1994 - ACS Publications
Revised Manuscript Received April 5, 1994® abstract: Phosphorylation-mediated regulation
of voltage-gated K+ channels has been implicated in numerous electrophysiological studies; …