Engineering synthetic vaccines using cues from natural immunity

DJ Irvine, MA Swartz, GL Szeto - Nature materials, 2013 - nature.com
Vaccines aim to protect against or treat diseases through manipulation of the immune
response, promoting either immunity or tolerance. In the former case, vaccines generate …

Materials engineering for immunomodulation

JA Hubbell, SN Thomas, MA Swartz - Nature, 2009 - nature.com
The engineering of materials that can modulate the immune system is an emerging field that
is developing alongside immunology. For therapeutic ends such as vaccine development …

Designing natural and synthetic immune tissues

EA Gosselin, HB Eppler, JS Bromberg, CM Jewell - Nature materials, 2018 - nature.com
Vaccines and immunotherapies have provided enormous improvements for public health,
but there are fundamental disconnects between where most studies are performed—in cell …

Biomaterials as tools to decode immunity

HB Eppler, CM Jewell - Advanced Materials, 2020 - Wiley Online Library
The immune system has remarkable capabilities to combat disease with exquisite selectivity.
This feature has enabled vaccines that provide protection for decades and, more recently …

Biomaterials-mediated engineering of the immune system

C Backlund, S Jalili-Firoozinezhad… - Annual review of …, 2023 - annualreviews.org
Modulation of the immune system is an important therapeutic strategy in a wide range of
diseases, and is fundamental to the development of vaccines. However, optimally safe and …

Improving vaccine and immunotherapy design using biomaterials

ML Bookstaver, SJ Tsai, JS Bromberg, CM Jewell - Trends in immunology, 2018 - cell.com
Polymers, lipids, scaffolds, microneedles, and other biomaterials are rapidly emerging as
technologies to improve the efficacy of vaccines against infectious disease and …

Targeted modulation of immune cells and tissues using engineered biomaterials

P Yousefpour, K Ni, DJ Irvine - Nature reviews bioengineering, 2023 - nature.com
Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …

Biomaterial strategies for immunomodulation

NA Hotaling, L Tang, DJ Irvine… - Annual review of …, 2015 - annualreviews.org
Strategies to enhance, suppress, or qualitatively shape the immune response are of
importance for diverse biomedical applications, such as the development of new vaccines …

Harnessing innate immunity using biomaterials for cancer immunotherapy

DY Lee, K Huntoon, Y Wang, W Jiang… - Advanced …, 2021 - Wiley Online Library
The discovery of immune checkpoint blockade has revolutionized the field of immuno‐
oncology and established the foundation for developing various new therapies that can …

Immunologically effective biomaterials

Q Wei, Y Su, H Xin, L Zhang, J Ding… - ACS Applied Materials & …, 2021 - ACS Publications
Immunoregulation represents a booming field of biomaterial design. The unique physical
and chemical properties of biomaterials offer tremendous opportunities for development …