An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both
bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine …

The etiologic agent of plague, Yersinia pestis, is a globally distributed pathogen which
poses both a natural and adversarial threat. Due largely to the rapid course and high …

An important virulence strategy evolved by bacterial pathogens to overcome host defenses
is the modulation of host cell death. Previous observations have indicated that Yersinia …

To evaluate the role of Yersinia outer proteins (Yops) in conferring protective immunity
against plague, six yop loci from Yersinia pestis were individually amplified by PCR, cloned …

Three great plague pandemics caused by the gram-negative bacterium Yersinia pestis have
killed nearly 200 million people and it has been linked to biowarfare in the past. Plague is …

Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y.
pestis evades the innate immune system by synthesizing tetra-acylated lipid A with poor Toll …

In a search for novel attenuated vaccine candidates for use against Yersinia pestis, the
causative agent of plague, a signature-tagged mutagenesis strategy was used and …

Current subunit vaccines provide partial protection against pneumonic plague if the infecting
Y. pestis strain is encapsulated (F1+). Here we describe YadC, a novel Y. pestis outer …

All strains of Yersinia pestis examined have been found to lack an O-antigen. In other
members of the Enterobacteriaceae, the rough phenotype often results in attenuation …

This study describes a PCR-based approach for the production of a rationally attenuated
mutant of Yersinia pestis. Degenerate primers were used to amplify a fragment encoding …