Post-hypoxic/ischemic neuroinflammation is selectively driven by sterile inflammation, which
implies the interplay of brain-intrinsic immune cells with other neural cells and immigrated …

Stroke is one of the leading causes of death and disability worldwide. NLRP3 inflammasome
has an essential role in the neuropathology of stroke. Recent studies report that shifting the …

NLRP3 inflammasome activation contributes to several pathogenic conditions, including
lipopolysaccharide (LPS)-induced sickness behavior characterized by reduced mobility and …

Background Sleep deprivation (SD) has many deleterious health effects, including cognitive
decline, work ability decline, inadequate alertness, etc. Neuroinflammation plays an …

Background Astrocyte-mediated neuroinflammation plays a critical role in ischemic stroke-
induced secondary cerebral injury. Previous studies have suggested that the dopamine D2 …

The NLRP3 inflammasome is activated in the early period following subarachnoid
hemorrhage (SAH), resulting in inflammatory responses. Recent studies have shown that …

Background and Purpose—A major process contributing to cell death in the ischemic brain
is inflammation. Inflammasomes are multimolecular protein complexes that drive …

Objective The NLRP3 (NALP3, cryopyrin) inflammasome, a key component of the innate
immune system, facilitates caspase‐1 and interleukin (IL)− 1β processing, which amplifies …

The pyrin domain-containing protein 3 (NLRP3) inflammasome drives the profound cerebral
ischemia and reperfusion injury (I/R) and mediates the secretion of IL-1β (interleukin-1β) …

Abstract Background α-Synuclein (α-Syn), a pathological hallmark of Parkinson's disease
(PD), has been recognized to induce the production of interleukin-1β in a process that …