Recent evidence suggests that Nod-like receptor protein-3 (NLRP3) inflammasome is a key
mediator of inflammatory response and can induce the activation of apoptosis signaling …

Abstract Background α-Synuclein (α-Syn), a pathological hallmark of Parkinson's disease
(PD), has been recognized to induce the production of interleukin-1β in a process that …

Chronic stress is a key risk factor for depression, and microglia have been implicated in the
pathogenesis of the disease. Recent studies show that the Nod-like receptor protein 3 …

Background The NLRP3 inflammasome is a multiprotein complex that regulates the innate
immune inflammatory response by activating caspase-1 and subsequent IL-1β and IL-18 …

Growing evidence has demonstrated that the nucleotide‑binding oligomerization domain‑
like receptor family pyrin domain containing 3 (NLRP‑3) inflammasome‑mediated …

Patients with chronic neuropathic pain (NP) have a significantly increased risk of central
nervous degeneration. Trigeminal neuralgia (TN) is a typical NP, and this manifestation is …

The nod-like receptor protein 3 (NLRP3) inflammasome has a critical role in inflammation
damage in ischemic injury, and the activation of the inflammasome is closely related to the …

Pupurpose of the study: Oxidative stress has been reported to be an important mechanism
for brain damage following ischemic stroke. Recently, the involvement of cytosolic receptors …

Background Inflammasomes are cytosolic multiprotein complexes which, upon assembly,
activate the maturation and secretion of the inflammatory cytokines IL‐1β and IL‐18 …

Ischemic stroke is a devastating disease with long-term disability. However, the
pathogenesis is unclear and treatments are limited. Meisoindigo, a second-generation …