Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. After the
initial primary mechanical injury, a complex secondary injury cascade involving oxidative …

Amyotrophic lateral sclerosis (ALS) is a disabling progressive disease characterized by the
degeneration of motor neurons, leading to muscle atrophy and paralysis. The majority of …

There is a great clinical need to identify the underlying mechanisms, as well as related
biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a …

Treatment for traumatic brain injury (TBI) remains elusive despite compelling evidence from
animal models for a variety of therapeutic targets. The activation of the NLRP3 (Nucleotide …

Infection, predominantly induced by gram-negative bacteria, is a critical health problem and
a leading cause of death worldwide. Advance of techniques, such as antibiotics and life …

The aseptic inflammatory response of the central nervous system is one of the important
causes of neurodegenerative diseases in individuals and is also recognized in …

Background Spinal cord injury (SCI) is a devastating disease, which results in tissue loss
and neurologic dysfunction. NLRP3 inflammasome plays an important role in the …

Background The NLRP3 inflammasome is a critical mediator of several vascular diseases
through positive regulation of proinflammatory pathways. In this study, we defined the role of …

The nod-like receptor protein 3 (NLRP3) inflammasome has a critical role in cerebral
ischemia. Autophagy may cause microglial inflammatory response or stimulate microglial …

Nucleotide oligomerization domain (NOD)-like receptor protein-3 (NLRP3) inflammasome
may intimately contribute to sustaining damage after traumatic brain injury (TBI). This study …