Infection, predominantly induced by gram-negative bacteria, is a critical health problem and
a leading cause of death worldwide. Advance of techniques, such as antibiotics and life …

Inflammation is a crucial factor contributing to secondary brain injury after intracerebral
haemorrhage (ICH). NLRP6, a member of nod-like receptors (NLRs) family, has been …

Background Spinal cord injury (SCI) is a devastating disease, which results in tissue loss
and neurologic dysfunction. NLRP3 inflammasome plays an important role in the …

Background Mitochondrial autophagy, the elimination of damaged mitochondria through
autophagy, contributes to neuron survival in cerebral ischemia. Long non-coding RNAs …

Background Parkinson's disease (PD) is a neurodegenerative disorder with progressive loss
of dopaminergic (DA) neurons. Systemic inflammation is shown to initiate and exacerbate …

Background: Evidence from both clinical and experimental research indicates that the
immune-brain interaction plays a pivotal role in the pathophysiology of depression. A multi …

Background Emerging studies have demonstrated the important physiological and
pathophysiological roles of hydrogen sulphide (H 2 S) as a gasotransmitter for NOD-like …

Sustained activation of NLRP3 inflammasome is closely related to diabetes and stroke.
However, it is unknown whether NLRP3 inflammasome plays an essential role in stroke in …

NLRP3 inflammasome has been considered as an important contributor to inflammation and
neuronal death after traumatic brain injury (TBI). Oridonin (Ori), the major active ingredient of …

Recently, a wealth of information has emerged connecting the activation of the NLRP3 (NOD-
like receptor family pyrin domain-containing 3) inflammasome to stroke pathogenesis …