[HTML][HTML] Hybrid gold (I) NHC-artemether complexes to target falciparum malaria parasites

M Ouji, G Barnoin, Á Fernández Álvarez, JM Augereau… - Molecules, 2020 - mdpi.com
The emergence of Plasmodium falciparum parasites, responsible for malaria disease,
resistant to antiplasmodial drugs including the artemisinins, represents a major threat to …

An overview of auric compounds as antimalarial agents and their action against essential targets of the parasite

GYS Delgado, M Navarro - Coordination Chemistry Reviews, 2024 - Elsevier
Malaria is one of the oldest and deadliest parasitic diseases globally, and it still poses a
global health issue today because of the emergence of new strains resistant to the first-line …

Design, Synthesis and Efficacy of Hybrid Triclosan‐gold Based Molecules on Artemisinin‐resistant Plasmodium falciparum and Leishmania infantum Parasites

M Ouji, SB Delmas, ÁF Álvarez, JM Augereau… - …, 2020 - Wiley Online Library
The emergence of resistant parasites, Plasmodium and Leishmania, responsible of malaria
and leishmaniasis diseases, to the currently available drugs, remains one of the major …

Antiplasmodial activities of gold (I) complexes involving functionalized N-heterocyclic carbenes

C Hemmert, AP Ramadani, L Boselli, AF Alvarez… - Bioorganic & medicinal …, 2016 - Elsevier
A series of twenty five molecules, including imidazolium salts functionalized by N-, O-or S-
containing groups and their corresponding cationic, neutral or anionic gold (I) complexes …

A Novel hybrid of chloroquine and primaquine linked by Gold (I): Multitarget and multiphase antiplasmodial agent

C de Souza Pereira, H Costa Quadros… - …, 2021 - Wiley Online Library
Plasmodium parasites kill 435 000 people around the world every year due to unavailable
vaccines, a limited arsenal of antimalarial drugs, delayed treatment, and the reduced clinical …

Synthesis, structures, and antimalarial activities of some silver (I), gold (I) and gold (III) complexes involving N-heterocyclic carbene ligands

C Hemmert, A Fabié, A Fabre, F Benoit-Vical… - European journal of …, 2013 - Elsevier
A series of mono-and dinuclear silver (I) and mononuclear gold (I) complexes containing bis
(N-heterocyclic carbene)(NHC) or N-functionalized NHC ligands were synthesized and fully …

Synthesis, in vitro antiplasmodial activity and cytotoxicity of a series of artemisinin–triazine hybrids and hybrid-dimers

TT Cloete, C de Kock, PJ Smith, DND David - European journal of …, 2014 - Elsevier
A series of artemisinin–triazine hybrids and hybrid-dimers were synthesized and their in vitro
antimalarial activity against the chloroquine sensitive (CQS), the gametocytocidal (NF54) …

Gold complexes as antimicrobial agents: an overview of different biological activities in relation to the oxidation state of the gold ion and the ligand structure

BĐ Glišić, MI Djuran - Dalton Transactions, 2014 - pubs.rsc.org
Interest in antimicrobial gold complexes originated from the work of Robert Koch at the end
of 19th century, who demonstrated that potassium dicyanidoaurate (I), K [Au (CN) 2], showed …

Novel metalloantimalarials: Transmission blocking effects of water soluble Cu (I), Ag (I) and Au (I) phosphane complexes on the murine malaria parasite Plasmodium …

S Tapanelli, A Habluetzel, M Pellei, L Marchiò… - Journal of Inorganic …, 2017 - Elsevier
The water soluble phosphane complexes [M (L) 4] PF 6 (M= Cu (I), Ag (I)) and [Au (L) 4] Cl
(L= thp (tris (hydroxymethyl) phosphane) or PTA (1, 3, 5-triaza-7-phosphaadamantane)) …

Gold complexes as potential anti-parasitic agents

M Navarro - Coordination Chemistry Reviews, 2009 - Elsevier
The medical uses of gold have a long history; rheumatoid arthritis is currently treated with
gold-based drugs and there is increasing interest in the application of gold complexes as …