Matrix-bound vesicles (MBVs) are embedded within osteoid and function as the site of initial
mineral formation. However, they remain insufficiently characterised in terms of biogenesis …

Extracellular vesicles comprise a heterogenous population of exosomes and microvesicles
that have critical roles in intercellular signalling and tissue development. These complex …

Osteoblast-derived extracellular vesicles (EV) are a collection of secreted (sEVs) and matrix-
bound nanoparticles that function as foci for mineral nucleation and accumulation. Due to …

The importance of matrix vesicles (MVs) has been repeatedly highlighted in the formation of
cartilage, bone, and dentin since their discovery in 1967. These nano-vesicular structures …

Extracellular vesicles (EV) are nano-sized bilayer vesicles that are involved in biological
functions and secreted by a wide variety of cells. Osteoblasts, the bone forming cells, can …

Bone biomineralization is a complex process that involves the deposition of calcium
phosphate crystals on collagen fibrils of the extracellular matrix (ECM). Although matrix …

Abstract Background Matrix vesicles (MVs) are released from hypertrophic chondrocytes
and from mature osteoblasts, the cells responsible for endochondral and membranous …

Matrix vesicles (MVs) play an important role in the initial stage of the process of bone
mineralization, and are involved in multiple rare skeletal diseases with pathological …

Matrix vesicles (MtVs) are one of the extracellular vesicles (EVs) secreted by osteoblasts.
Although MtVs have a classically-defined function as an initiator of ossification and recent …

Mineralization-competent cells release a special class of matrix-bound extracellular
vesicles, also named matrix vesicles (MVs), which are the responsible for the deposition of …