Hippocampal neurogenesis in the APP/PS1/nestin-GFP triple transgenic mouse model of Alzheimer's disease

Q Zeng, M Zheng, T Zhang, G He - Neuroscience, 2016 - Elsevier
Alzheimer's disease (AD) is one of the most common causes of dementia. Although the
exact mechanisms of AD are not entirely clear, the impairment in adult hippocampal …

[HTML][HTML] Early changes in hippocampal neurogenesis in transgenic mouse models for Alzheimer's disease

MS Unger, J Marschallinger, J Kaindl, C Höfling… - Molecular …, 2016 - Springer
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the Western
world and is characterized by a progressive loss of cognitive functions leading to dementia …

[HTML][HTML] Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease

JJ Rodríguez, VC Jones, M Tabuchi, SM Allan… - PloS one, 2008 - journals.plos.org
It has become generally accepted that new neurones are added and integrated mainly in
two areas of the mammalian CNS, the subventricular zone and the subgranular zone (SGZ) …

Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model

Y Yu, J He, Y Zhang, H Luo, S Zhu, Y Yang… - …, 2009 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with
senile β‐amyloid (Aβ) plaques and cognitive decline. Neurogenesis in the adult …

Limited hippocampal neurogenesis in SAMP8 mouse model of Alzheimer's disease

B Gang, C Yue, N Han, H Xue, B Li, L Sun, X Li, Q Zhao - Brain research, 2011 - Elsevier
Increasing adult neurogenesis in the hippocampal formation (HF) has been proposed as a
potential foundation for neuronal repair in Alzheimer's disease (AD), but the evidence …

[HTML][HTML] Modulating adult neurogenesis affects synaptic plasticity and cognitive functions in mouse models of Alzheimer's disease

X Zhang, X Wei, Y Mei, D Wang, J Wang, Y Zhang, X Li… - Stem cell reports, 2021 - cell.com
New neurons are abnormal in the adult hippocampus of Alzheimer's disease (AD) mouse
models. The effects of modulating adult neurogenesis on AD pathogenesis differ from study …

Neurogenic responses to amyloid-beta plaques in the brain of Alzheimer's disease-like transgenic (pPDGF-APPSw, Ind) mice

L Gan, S Qiao, X Lan, L Chi, C Luo, L Lien, QY Liu… - Neurobiology of …, 2008 - Elsevier
Formation and accumulation of amyloid-beta (Aβ) plaques are associated with declined
memory and other neurocognitive function in Alzheimer's disease (AD) patients. However …

[HTML][HTML] Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt/β-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic …

Q Zeng, Z Long, M Feng, Y Zhao, S Luo… - Frontiers in aging …, 2019 - frontiersin.org
Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by the
deposition of amyloid-β (Aβ) peptides and neurofibrillary tangles (NFTs) and massive loss of …

Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APPswe/PS1ΔE9 transgenic mouse model of Alzheimer's disease

J Tang, M Song, Y Wang, X Fan, H Xu, Y Bai - Biochemical and biophysical …, 2009 - Elsevier
In addition to the subventricular zone, the dentate gyrus of the hippocampus is one of the
few brain regions in which neurogenesis continues into adulthood. Perturbation of …

[HTML][HTML] Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer's disease by compromising hippocampal inhibition

C Hollands, MK Tobin, M Hsu, K Musaraca… - Molecular …, 2017 - Springer
Background The molecular mechanism underlying progressive memory loss in Alzheimer's
disease is poorly understood. Neurogenesis in the adult hippocampus is a dynamic process …