898 HUNTER & COOPER cleotides had set a precedent, reports of orthophosphate
esterified to tyrosine did not emerge until 1979 (1). Phosphotyrosine (P. Tyr) was first …

Publisher Summary This chapter describes viral protein-tyrosine kinases and discusses their
roles in viral transformation. For this, the properties of the individual viral protein-tyrosine …

Publisher Summary This chapter discusses the detection and quantification of
phosphotyrosine in proteins. Protein kinases can be differentiated according to their amino …

Using a synthetic peptide (Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Arg-Arg-Gly) as a substrate,
various normal tissues from the rat were probed for tyrosine protein kinase activity. Spleen …

Protein phosphorylation involves the transfer of phosphate from a nucleotide (usually ATP)
to a substrate protein, catalyzed by a protein kinase. The activily of this substrate protein is …

Protein kinases associated with the transforming proteins of a number of retroviruses are
specific for tyrosine. Several proteins in cells transformed by these viruses are …

The major in vitro substrate for a tyrosine protein kinase in the particular fraction of the
lymphoma cell line LSTRA is a protein of approximately 58,000 daltons (pp58). In order to …

It is a great honour to give the Eighteenth Hopkins Memorial Lecture, and to join the
distinguished list of past recipients of this medal. In particular, it gives me much pleasure to …

The protein tyrosine phosphatases comprise a family of enzymes that specifically
dephosphorylate tyrosyl residues. Determination of the amino acid sequence of a major low …

The particulate fraction from a lymphoma cell line, LSTRA, was found to contain an apparent
high level of tyrosine protein kinase activity. When this fraction was incubated with [gamma …