[HTML][HTML] Amyotrophic lateral sclerosis: an update for 2013 clinical features, pathophysiology, management and therapeutic trials

PH Gordon - Aging and disease, 2013 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS), first described by Jean-Martin Charcot in the 1870s, is
an age-related disorder that leads to degeneration of motor neurons. The disease begins …

Current view and perspectives in amyotrophic lateral sclerosis

S Mathis, P Couratier, A Julian, P Corcia… - Neural Regeneration …, 2017 - journals.lww.com
Amyotrophic lateral sclerosis (ALS), identified as a distinct clinical entity by Charcot since the
end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that …

Emerging drugs for amyotrophic lateral sclerosis

AA Habib, H Mitsumoto - Expert opinion on emerging drugs, 2011 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative
disease that results in increasing disability and that is uniformly fatal. Since its approval in …

Potential therapeutic drugs and methods for the treatment of amyotrophic lateral sclerosis

G Yacila, Y Sari - Current medicinal chemistry, 2014 - ingentaconnect.com
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder caused by damage of
motoneurons leading to paralysis state and long term disability. Riluzole is currently the only …

Therapies in amyotrophic lateral sclerosis–beyond riluzole

KE Morrison - Current opinion in pharmacology, 2002 - Elsevier
Several mechanisms have been proposed to account for the progressive motor neurone
death evident in amyotrophic lateral sclerosis. These include oxidative stress, neurofilament …

Therapeutic development in amyotrophic lateral sclerosis

M Bucchia, A Ramirez, V Parente, C Simone… - Clinical …, 2015 - Elsevier
Purpose Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in
adults. It is almost invariably lethal within a few years after the onset of symptoms. No …

Current therapy of drugs in amyotrophic lateral sclerosis

H Lu, WD Le, YY Xie, XP Wang - Current neuropharmacology, 2016 - ingentaconnect.com
Amyotrophic lateral sclerosis (ALS), commonly termed as motor neuron disease (MND) in
UK, is a chronically lethal disorder among the neurodegenerative diseases, meanwhile. ALS …

Molecular insights and therapeutic targets in amyotrophic lateral sclerosis

A Al-Chalabi, VB Tripathi - CNS & Neurological Disorders-Drug …, 2008 - ingentaconnect.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons
resulting in progressive paralysis and respiratory failure. About 1 in every 400 people dies of …

Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment

EF Goodall, KE Morrison - Expert reviews in molecular medicine, 2006 - cambridge.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by
loss of motor neurons. The cause of disease is unknown other than in the rare cases of …

Managing amyotrophic lateral sclerosis: slowing disease progression and improving patient quality of life

BR Brooks - Annals of neurology, 2009 - Wiley Online Library
It is now possible to slow the disease progression of amyotrophic lateral sclerosis (ALS), but
documented improvement in the quality of life of ALS patients has been difficult to quantitate …