Abnormal glutamate metabolism is one of the most plausible explanations of the ALS
disease process.'Patients with ALS are less able to metabolize oral monosodium glutamine …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder of the central
nervous system (CNS) with an unknown etiology. This disorder is characterized clinically by …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease associated
with a life expectancy of approximately 3 years after symptom onset, but the range of survival …

Selective motoneurons (MNs) degeneration in the brain stem, hypoglossal motoneurons
(HMNs), and the spinal cord resulting in patients paralysis and eventual death are prominent …

Since its first description by Charcot over 120 years ago, amyotrophic lateral sclerosis (ALS)
has remained an enigmatic disease. However, significant advances have been made during …

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease that rapidly
progresses from mild motor symptoms to severe motor paralysis and premature death. There …

Tremendous advances in our understanding of pathogenesis of amyotrophic lateral
sclerosis (ALS) have provided a rich pipeline of drugs for clinical trialists. At least 32 unique …

Since its description by Charcot more than 130 years ago, the pathogenesis of selective
motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remains unsolved. Over …

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease characterised by
the selective death of motor neurons. The mechanisms and processes responsible for the …

Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease of the
human motor system. Aetiological mechanisms implicated in the development of ALS have …