Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs
MK Jaiswal - Medicinal Research Reviews, 2019 - Wiley Online Library
Over the past decades, a multitude of experimental drugs have been shown to delay
disease progression in preclinical animal models of amyotrophic lateral sclerosis (ALS) but …
disease progression in preclinical animal models of amyotrophic lateral sclerosis (ALS) but …
Riluzole: real-world evidence supports significant extension of median survival times in patients with amyotrophic lateral sclerosis
M Hinchcliffe, A Smith - Degenerative neurological and …, 2017 - Taylor & Francis
Amyotrophic lateral sclerosis (ALS) is the commonest form of motor neuron disease and is a
fatal, degenerative, multisystem disorder affecting upper and/or lower motor neurons in the …
fatal, degenerative, multisystem disorder affecting upper and/or lower motor neurons in the …
The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by
progressive loss of muscle function. It is the most common adult‐onset form of motor neuron …
progressive loss of muscle function. It is the most common adult‐onset form of motor neuron …
Amyotrophic lateral sclerosis: current therapeutic perspectives
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by
progressive motor neuron degeneration, muscle weakness, paralysis, and ultimately death …
progressive motor neuron degeneration, muscle weakness, paralysis, and ultimately death …
[HTML][HTML] Shortcomings in the current amyotrophic lateral sclerosis trials and potential solutions for improvement
N Katyal, R Govindarajan - Frontiers in neurology, 2017 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a clinically progressive neurodegenerative syndrome
predominantly affecting motor neurons and their associated tracts. Riluzole and edaravone …
predominantly affecting motor neurons and their associated tracts. Riluzole and edaravone …
[HTML][HTML] Translating preclinical insights into effective human trials in ALS
AB DiBernardo, ME Cudkowicz - … et Biophysica Acta (BBA)-Molecular Basis …, 2006 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, adult-onset neurodegenerative
disease characterized by selective dysfunction and death of motor neurons in the brain and …
disease characterized by selective dysfunction and death of motor neurons in the brain and …
Emerging targets and treatments in amyotrophic lateral sclerosis
L Zinman, M Cudkowicz - The Lancet Neurology, 2011 - thelancet.com
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that is currently
untreatable. Many compounds have been tested in laboratory-based models and in patients …
untreatable. Many compounds have been tested in laboratory-based models and in patients …
Clinical trials for neuroprotection in ALS
G Siciliano, C Carlesi, L Pasquali… - CNS & Neurological …, 2010 - ingentaconnect.com
Owing to uncertainty on the pathogenic mechanisms underlying motor neuron degeneration
in amyotrophic lateral sclerosis (ALS) riluzole remains the only available therapy, with only …
in amyotrophic lateral sclerosis (ALS) riluzole remains the only available therapy, with only …
Therapeutic progress in amyotrophic lateral sclerosis-beginning to learning
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with
motor neuron degeneration, muscle weakness, paralysis and finally death. The proposed …
motor neuron degeneration, muscle weakness, paralysis and finally death. The proposed …
Glutamate pathway implication in amyotrophic lateral sclerosis: what is the signal in the noise?
V Le Verche, B Ikiz, A Jacquier… - Journal of Receptor …, 2010 - Taylor & Francis
The cause of the fatal motor neuron disease, amyotrophic lateral sclerosis (ALS), remains
largely unknown. Most cases of ALS are sporadic and, for~ 20% of familial ALS patients …
largely unknown. Most cases of ALS are sporadic and, for~ 20% of familial ALS patients …