Circulation. 2017; 136: 680–686. DOI: 10.1161/CIRCULATIONAHA. 117.029343 August 15,
2017 681 proliferation. 5 It remains unclear whether this regenerative window exists in large …

The regenerative capacity of the heart has long fascinated scientists. In contrast to other
organs such as liver, skin, and skeletal muscle, the heart possesses only a minimal …

The newt and the zebrafish have the ability to regenerate many of their tissues and organs
including the heart. Thus, a major goal in experimental medicine is to elucidate the …

The adult human heart does not regenerate significant amounts of lost tissue after injury.
Rather than making new, functional muscle, human hearts are prone to scarring and …

Cardiomyocyte proliferation and progenitor differentiation are endogenous mechanisms of
myocardial development. Cardiomyocytes continue to proliferate in mammals for part of post …

After decades of believing the heart loses the ability to regenerate soon after birth, numerous
studies are now reporting that the adult heart may indeed be capable of regeneration …

Acute myocardial infarction leads to irreversible loss of cardiac myocytes, thereby
diminishing the pump function of the heart. As a result, the strenuous workload imposed on …

Cardiac regeneration is a rapidly evolving and controversial field of research. The
identification some 12 years ago of progenitor cells that reside within the heart spurred …

▪ Abstract Many forms of pediatric and adult heart disease result from a deficiency in
cardiomyocyte number. Through repopulation of the heart with new cardiomyocytes (that is …

The capacity of the mammalian heart to regenerate cardiomyocytes has been debated over
the last decades. However, limitations in existing techniques to track and identify nascent …