Abstract The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several
enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate …

The aims of this study were to develop a robust method for simultaneous quantification of
carboxylesterases (CESs) 1 and 2 and to quantify those absolute protein levels in human …

Abstract Carboxylesterase 1 (CES1) is a primary human hepatic hydrolase involved in
hydrolytic biotransformation of numerous medications. Considerable interindividual …

A series of studies were designed and carried out in order to explore the potential for the
major human hepatic hydrolase, carboxylesterase 1 (hCES1), to serve as a target of …

Carboxylesterase (CES) is important for the detoxification of a wide range of drugs and
xenobiotics. In this study, the hepatic level of CES2 mRNA was examined in cynomolgus …

Mammalian carboxylesterase 1 enzymes can hydrolyze many xenobiotic chemicals and
endogenous lipids. We here identified and characterized a mouse strain (FVB/NKI) in which …

Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …

Carboxylesterases (CESs) play major roles in catalyzing the hydrolysis of a wide range of
ester-and amide-containing compounds. CESs dominate both the biotransformation of …

Carboxylesterase (CES) is important for detoxification of a wide range of drugs and
xenobiotics and catalyzes cholesterol and fatty acid metabolism. Cynomolgus macaques are …

Abstract Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes,
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …