The carboxylesterases (CESs) are a family of serine hydrolases that hydrolyze compounds
containing an ester, amide, or thioester. In humans, two dominant forms, CES1 and CES2 …

Carboxylesterase 1 (CES1) is the predominant human hepatic hydrolase responsible for the
metabolism of many clinically important medications. CES1 expression and activity vary …

Abstract Human carboxylesterase 2 (CES2A), one of the most abundant hydrolases
distributed in human small intestine and colon, play key roles in the hydrolysis of a wide …

Human carboxylesterases 1 and 2 (CES1 and CES2) catalyze the hydrolysis of many
exogenous compounds. Alterations in carboxylesterase sequences could lead to variability …

Several mouse carboxylesterase (CES) isozymes have been identified, but information
about their roles in drug metabolism is limited. In this study, we purified and characterized a …

Abstract Background and Objective Human carboxylesterase-1 (CES1) is an enzyme that is
primarily expressed in the liver, where it plays an important role in the metabolism of many …

Abstract Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine
esterases responsible for the hydrolysis of ester and amide bonds present in a number of …

Abstract The carboxylesterase 1 gene (CES1) encodes a hydrolase that metabolizes
commonly used drugs. The CES1-related pseudogene, carboxylesterase 1 pseudogene 1 …

Carboxylesterase 1 (CES1) metabolizes methylphenidate and other drugs. CES1 gene
variation only partially explains pharmacokinetic (PK) variability. Biomarkers predicting the …

Abstract Background and Objective Human carboxylesterase-1 (CES1) and human
carboxylesterase-2 (CES2) play an important role in metabolizing many medications …