Abstract Background and Objective Human carboxylesterase-1 (CES1) and human
carboxylesterase-2 (CES2) play an important role in metabolizing many medications …

Carboxylesterases (CES) metabolize esters. Two CES isoforms are expressed in human
liver (CES1 and CES2) and liver extracts are used in reaction phenotyping studies to discern …

Carboxylesterases belong to Phase I group of drug metabolizing enzymes. They hydrolyze a
variety of drug esters, amides, carbamates and similar structures. There are five …

Objective CES1 encodes carboxylesterase-1, an important drug-metabolizing enzyme with
high expression in the liver. Previous studies have reported a genomic translocation of the …

Carboxylesterase 1 (CES1) is the major hepatic hydrolytic enzyme responsible for the
metabolism of many therapeutic agents, toxins, and endogenous compounds existing as …

Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …

Human carboxylesterase (CES) 1 and CES2 are members of the serine hydrolase
superfamily, and both exhibit broad substrate specificity and are involved in xenobiotic and …

Abstract Carboxylesterase 1 (CES1) is implicated in the metabolism of several commonly
used drugs and other xenobiotics. The gene encoding this enzyme, CES1, is duplicated in …

Abstract Carboxylesterases 1A (CES1A) is a key enzyme responsible for the hydrolytic
metabolism of a great deal of endogenous and exogenous substrates bearing ester-or …

Carboxylesterases (CEs) are ubiquitously expressed proteins that are responsible for the
detoxification of xenobiotics. They tend to be expressed in tissues likely to be exposed to …