Objectives: To assess the relationship between the presence of DHFR and DHPS mutations
in Plasmodium falciparum, parasite in vitro resistance, and in vivo efficacy of sulfadoxine …

Objective To determine the relationship between mutations in dhfr and dhps and SP
treatment failure in Plasmodium falciparum malaria in the Democratic Republic of the Congo …

ABSTRACT A total of 252 children were enrolled in a drug trial to assess the effect of
minimal doses of sulfadoxine (Sdx) and pyrimethamine (Pyr). Parasite samples isolated from …

A quantitative nucleic acid sequence-based amplification (QT-NASBA) assay was employed
to predict retrospectively the outcome of sulfadoxine–pyrimethamine (SP) treatment of …

Molecular assays for monitoring sulfadoxine-pyrimethamine-resistant Plasmodium
falciparum have not been implemented because of the genetic and statistical complexity of …

Mutations in Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate
synthase (dhps) genes have been used as means to predict treatment failure to sulfadoxine …

Both use of sulphadoxine‐pyrimethamine (SP) and SP‐resistance of Plasmodium
falciparum are increasing in sub‐Saharan Africa. Mutations in the P. falciparum …

Abstract Background The Plasmodium falciparum dihydrofolate reductase (PfDHFR)
inhibitors pyrimethamine and cycloguanil (the active metabolite of proguanil) have important …

A total of 70 Plasmodium falciparum isolates were tested in vitro against pyrimethamine
(PYR), trimethoprim (TRM), sulfadoxine (SDX), and sulfamethoxazole (SMX), and their …

Several in vitro studies have shown the correlation between mutations in dhfr and dhps
genes and resistance to pyrimethamine/sulfadoxine (PYR/SDX) combination, but the in vivo …