Calcium acts as a second messenger and plays a crucial role in signaling pathways
involved in cell proliferation. Recently, calcium channels related to calcium influx into the …

Differentiation of lineage-committed cells from multipotent progenitors requires the
establishment of accessible chromatin at lineage-specific transcriptional enhancers and …

The growth of cancer cells as oncospheres in three-dimensional (3D) culture provides a
robust cell model for understanding cancer progression, as well as for early drug discovery …

The endocytic adaptor protein Numb has a major role in development as an intrinsic
regulator of cell fate determination and inhibitor of the Notch signaling pathway. In …

Differentially expressed nucleolar transforming growth factor-β1 target (DENTT), also known
as testis-specific protein Y-encoded-like (TSPYL-2) and cell division autoantigen-1, is a …

Mammalian NUMB is alternatively spliced generating four isoforms NUMB1‐NUMB4 that
can function as tumor suppressors. NUMB1‐NUMB4 proteins, which normally determine …

The tumor suppressor Bin1 was identified through its interaction with the N-terminal region
of Myc which harbors its transcriptional activation domain. Here we show that Bin1 and Myc …

The transforming growth factor-β1 (TGF-β1) responsive epithelial non-small-cell lung cancer
(NSCLC) cell line NCI-H727 was used to identify potential target genes involved in TGF-β1 …

Transcriptional programs in embryogenesis and cancer, such as the epithelial-to-
mesenchymal transition (EMT), ensure cellular plasticity, an essential feature of carcinoma …

Genes that modify oncogenesis may influence dormancy versus progression in cancer,
thereby affecting clinical outcomes. The Bin1 gene encodes a nucleocytosolic adapter …