Purpose: Head and neck squamous cell carcinoma (HNSCC) represents the sixth most
frequent type of cancer worldwide. However, the molecular genetic alterations underlying its …

BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …

By analyzing the cDNA obtained from 16 B-cell chronic lymphocytic leukemia (B-CLL)
patient samples, we found that Nutlin-3, a small molecule inhibitor of MDM2/p53 interaction …

Chromatin remodeling proteins regulate multiple aspects of cell homeostasis, making them
ideal candidates for misregulation in transformed cells. Here, we explore Sin3A, a member …

Background Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a
phosphatase having both protein and lipid phosphatase activities, and is known to …

Nutlin-3, a small molecule regulator of the tumor suppressor p53, targets the interaction
between p53 and murine double minute 2 (MDM2) thereby promoting stabilization of p53 …

Bromodomain and extraterminal (BET) proteins are epigenetic" readers" that recognize
acetylated histones and mark areas of the genome for transcription. BRD4, a BET family …

Differentially expressed nucleolar TGF‐β1 target (DENTT) is a recently identified gene
whose mRNA is differentially affected by TGF‐β1 in TGF‐β1–responsive human lung cancer …

The loss of contact inhibition is a key step during carcinogenesis. The Hippo–Yes-
associated protein (Hippo/YAP) pathway is an important regulator of cell growth in a cell …

Ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR)
kinases have been considered the primary activators of the cellular response to DNA …