Study Objective. To investigate the early blood pressure effects of vasopressin compared
with titrated catecholamines as initial drug therapy in patients with septic shock. Design …

Purpose It is not clear whether vasopressin versus norepinephrine changed mortality in
clinical practice in the Vasopressin and Septic Shock Trial (VASST) coordinating center …

Background: There is little data guiding clinicians on how to discontinue vasopressors
among septic shock patients on concomitant norepinephrine (NE) and vasopressin (VP) …

The definition of septic shock includes sepsis-induced hypotension despite adequate fluid
resuscitation, along with the presence of organ perfusion abnormalities, and ultimately cell …

Background: Septic shock is a distributive shock with decreased systemic vascular
resistance and MAP. Septic shock contributes to the most common causes of death in the …

Background: The optimal adjuvant vasopressor to norepinephrine in septic shock remains
controversial. Objective: To compare durations of shock-free survival between adjuvant …

Vasopressin is a potent vasopressor for improving organ perfusion during septic shock. The
rationale for the use of vasopressin is its relative deficiency of plasma levels and …

Limiting excess of fluid administration therefore seems appropriate, but it could be
counterbalanced by the thought potential harm of using vasoactive drugs when hypovolemia …

Vasopressin in septic shock Page 1 JICS Volume 12, Number 1, January 2011 11 Review
articles © The Intensive Care Society 2011 Rationale Mechanism of action Vasopressin (also …

Septic shock is one of the most challenging problems in critical care medicine. Shock due to
sepsis accounts for many of the deaths in medical and surgical intensive care units. 1-4 It is …