The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication

J Li, Q Gui, FX Liang, J Sall, Q Zhang, Y Duan… - Journal of …, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like other coronaviruses,
replicates their genome in virus-induced cytosolic membrane-bound replication organelles …

Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication

JM Williams, YJ Chen, WJ Cho, AW Tai, B Tsai - Journal of Cell Biology, 2023 - rupress.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiologic agent for the
global COVID-19 pandemic, triggers the formation of endoplasmic reticulum (ER)-derived …

RTN3 and RTN4: Architects of SARS-CoV-2 replication organelles

A Kratzel, V Thiel - Journal of Cell Biology, 2023 - rupress.org
SARS-CoV-2 depends on host proteins for successful replication. In this issue, Williams et
al.(2023. J. Cell Biol. https://doi. org/10.1083/jcb. 202203060) report that the ER membrane …

[HTML][HTML] Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2

V Prasad, B Cerikan, Y Stahl, K Kopp, V Magg… - Molecular Cell, 2023 - cell.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remodels the endoplasmic
reticulum (ER) to form replication organelles, leading to ER stress and unfolded protein …

Identification of host dependency factors involved in SARS-CoV-2 replication organelle formation through proteomics and ultrastructural analysis

F Pahmeier, TM Lavacca, S Goellner… - Journal of …, 2023 - Am Soc Microbiol
Positive-strand RNA viruses subvert the cellular endomembrane system for the generation
of distinct compartments termed replication organelles (ROs) that harbor the site where viral …

Molecular mechanisms for understanding the association between TMPRSS2 and beta coronaviruses SARS-CoV-2, SARS-CoV and MERS-CoV infection: Scoping …

MJ Chaves-Medina, JC Gomez-Ospina… - Archives of …, 2022 - Springer
The aim of this scoping review was to identify knowledge gaps and to describe the current
state of the research on the association between TMPRSS2 and the essential beta …

The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle

S Ricciardi, AM Guarino, L Giaquinto, EV Polishchuk… - Nature, 2022 - nature.com
Abstract SARS-CoV-2, like other coronaviruses, builds a membrane-bound replication
organelle to enable RNA replication. The SARS-CoV-2 replication organelle is composed of …

EGR1 functions as a new host restriction factor for SARS-CoV-2 to inhibit virus replication through the E3 ubiquitin ligase MARCH8

Y Zhao, L Sui, P Wu, L Li, L Liu, B Ma, W Wang… - Journal of …, 2023 - Am Soc Microbiol
Coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has led to an unprecedented public health crisis worldwide. Though the host …

TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution

B Qu, C Miskey, A Gömer… - Proceedings of the …, 2024 - National Acad Sciences
The accessory protease transmembrane protease serine 2 (TMPRSS2) enhances severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uptake into ACE2-expressing …

TMPRSS11D and TMPRSS13 activate the SARS-CoV-2 spike protein

M Kishimoto, K Uemura, T Sanaki, A Sato, WW Hall… - Viruses, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) utilizes host proteases,
including a plasma membrane-associated transmembrane protease, serine 2 (TMPRSS2) to …