Gastric carcinoma (GC) is a biologically heterogeneous disease involving numerous genetic
and epigenetic alterations. A very small proportion of GCs can be caused by a specific germ …

Gastric cancer (GC) represents an important contributor to the global burden of cancer,
being one of the most common and deadly malignancies worldwide. According to TCGA and …

The relevance of the clinicopathological and molecular features of early gastric cancers
(EGCs) having the microsatellite instability (MSI)‐high phenotype has not been clearly …

Gastric cancer (GC) is the fifth most common cancer in the world and accounts for 7% of the
total cancer incidence. The prognosis of GC is dismal in Western countries due to late …

AIM: Mitogen-activated protein kinase (MAPK) cascade and phosphatidylinositol 3-kinase
(PI3K) survival pathways are frequently activated in the progression of gastrointestinal …

In gastric cancer (GC) the loss of genomic stability represents a key molecular step that
occurs early in the carcinogenesis process and creates a permissive environment for the …

The development of gastric adenocarcinoma is a complex multistep process involving
multiple genetic alterations. Based on pathology, four different macroscopic types and at …

Gastric cancer is one of the most aggressive malignancies, with limited treatment options in
both locally advanced and metastatic setting, resulting in poor prognosis. Based on genomic …

Loss of DNA mismatch repair (MMR) function, due to somatic or germline epi/genetic
alterations of MMR genes leads to the accumulation of numerous mutations across the …

Key clinicopathologic features of microsatellite instability–positive (MSI+) gastric cancers
(GCs) are that they tend to be located in the antrum and have an intestinal phenotype and …